Development of a high-throughput screening system for SARS CoV-2 variants and screening for novel antivirals

The COVID-19 pandemic is the greatest public health disaster in over a century resulting in the death of nearly 6 million people world-wide. The virus has evolved over the last two years to highly transmissible variants, outpacing our efforts to contain it by mass vaccination. Effective drugs that can curtail the infection at early stages, preventing transmission and hospitalizations are essential to limit community spread of the new, highly transmissible variants.

Development of novel oromucosal formulation based on a filmstrip technology for the delivery of psychedelic medications

New evidence about psychedelic remedies has increased the number of patients who potentially can benefit from therapies using these drugs. In clinical trials worldwide, the findings are reported on psychedelic medications for treating illnesses such as addiction, depression, anxiety, and mental health conditions like post-traumatic stress disorder (PTSD). If psychedelic drugs are orally administered, the bioavailability can significantly decrease due to the first-pass metabolism of the liver.

Visualization and Characterization of Novel Coronavirus Structure using Ultrasonic-Atomic Force Microscopy Targeted for anti-COVID-19 Therapeutics

SARS-CoV-2, the virus responsible for the current COVID-19 pandemic, displays a coronashaped layer of spikes which play fundamental role in the infection process. Recent structural data suggest that the spikes possess orientational freedom and the ribonucleoproteins segregate into basketlike structures. How these structural features regulate the dynamic and mechanical behavior of the native virion, however, remain unknown.

Evaluation of PLO Micelles for Transdermal Peptide Delivery to Superficial Bone

This research aims to develop and test a transdermal delivery system for small bone healing peptide hormones. Peptides and many drug molecules do not usually penetrate the outer skin barrier, the stratum corneum, in order to treat the underlying body tissues. However, by using liposomal gel as a drug delivery medium, it is often possible to impart the transdermal delivery of several analgesic drugs, lipophilic hormones and even small peptides by using augmentative technologies.

Towards developing inhibitors to treat CoVID-19

The SARS-CoV-2 outbreak, which started in Dec. 2019, has so far not been contained due to unpreparedness and unsuccessful development of antiviral drugs against SARS-CoV-2. In response to this pandemic, we propose strategies for the development of novel antiviral agents against a number of known viral targets using in-silico modeling and laboratory testing to rapidly identify and validate their efficiency in blocking viral functions.

Investigation into molecular mechanism of CRV431, a cyclophilin inhibitor, for anti-fibrotic and anti-oncogenic potential in various animal models

Various liver disorders such as fatty liver, liver fibrosis, liver failure and liver cancer, are major healthcare burden and associated with high rate of mortality. Once fatty liver or fibrosis progress to cirrhosis or liver failure, its treatment is challenging due to lack of an effective treatment. Currently available treatment for liver cancer is few anticancer drugs or surgical ablation with liver transplantation. However, available pharmacological interventions have not succeeded fully.

Stability and antioxidant properties of pharmaceutical and nutraceutical products

Nutraceuticals are being used ubiquitously, but seldom undergo rigorous testing. This study is focused on two primary aspects of studying natural health products, specific cannabis and its oils. The first objective is to determine the shelf life (product stability) by performing a series of tests to accelerate the ageing process in order to provide an estimation of shelf life. Currently, cannabis oils have arbitrary assignments of expiry dates, if at all. The other key focus involves studying the antioxidant benefits (or pro-oxidant detriment) imparted by cannabis products.

Preparatory research to enable the implementation of a multi-site research project: Getting it right - Pharmacist-led pharmacogenetic testing in community pharmacies

Making sure patients have well controlled post-operative pain is imperative for patient well-being, optimal recovery, and to prevent chronic pain from developing. Opioid medications are often used to treat post-surgical pain, but some people respond in unpredictable ways and this may be related to their genetics. Pharmacogenetic (PGx) testing is a way of finding out how people’s genes affect the way they respond to medications.