Characterization of a Biolubricant Based on Sulfated Polysaccharide Derived from Brown Algae

Lubricant is the substance used to decrease the friction generated between the two surfaces undergo relative motion. There are many applications for naturally occurring lubricants in medical field to improve a patient’s quality of life. Fucoidan is one of the naturally occurring lubricants that has the potential of reducing adhesion after an abdominal surgery. ARC Medical devices have developed an advanced manufacturing process to produce ultra-pure fucoidan that’s more suitable for clinical application.

Characterization of a Biolubricant Based on Sulfated Polysaccharide Derived from Brown Algae

Lubricant is the substance used to decrease the friction generated between the two surfaces undergo relative motion. There are many applications for naturally occurring lubricants in medical field to improve a patient’s quality of life. Fucoidan is one of the naturally occurring lubricants that has the potential of reducing adhesion after an abdominal surgery. ARC Medical devices have developed an advanced manufacturing process to produce ultra-pure fucoidan that’s more suitable for clinical application.

Preparation of a new formulation to prevent surgical adhesions

Inter-tissue adhesions cause significant complications following veterinary surgery of domesticated animals. Fucoidans are natural, negatively charged, carbohydrate polymers (polysaccharides) from seaweeds that have been successfully developed and commercialized for reducing such adhesions, thereby improving surgical outcomes. Currently, the inherent variability in the molecular size and composition of native fucoidans extracted from seaweed presents a significant barrier for their break-through application in human surgery.

Characterizing fucoidan-degrading enzymes from marine bacterium

Fucoidan is a polysaccharide found in brown algae (seaweed). ARC Medical Devices Inc. markets fucoidan purified from brown algae for post-surgical veterinary use to reduce interorgan adhesion development. This product works very effectively, prompting a desire to develop a similar product for use in humans. The challenge to this, however, is that fucoidan is an extremely large molecule of heterogeneous composition, making it difficult to meet the higher standards of purity and homogeneity required of medical materials for use in human subjects.