Diseases, such as inflammatory bowel disease, rheumatoid arthritis, and osteoarthritis have been widely impacted by the pathogenesis of inflammation. After traditional therapy, most of the time dying cells stimulate inflammatory effects which results the reduction of therapeutic effect and enhances the drug resistance. That is why treatment often requires frequent or continuous high-dosage administration of anti-inflammatory drugs. Efficient delivery of anti-inflammatory drugs to the targeted sites can reduce medical dosage and improve therapeutic effect.