Therapeutic Strategies for Restoring Palmitoylation and Autophagy in Neurodegeneration

The cellular clearance pathway autophagy is required for degrading toxic proteins and damaged organelles, but is disrupted in many neurodegenerative diseases. During induction many autophagy regulators quickly localise to membranes from the cytosol. The Martin lab has identified palmitoylation, which involves the addition of the fatty acid palmitate to cysteine residues, as a potential regulator to direct autophagy proteins to membranes.