Understanding the role and regulation of follicular fluid miRNAs in ovarian function and polycystic ovarian syndrome. 1

The polycystic ovarian syndrome (PCOS), a multi-factorial heterogeneous syndrome with complex pathologies, affects up to 10% of women of reproductive age and accounts for 75% of anovulatory infertility. PCOS is associated with follicle growth arrest at the early antral stage, chronic anovulation, minimal granulosa cell proliferation, hyperthecosis with hyperandrogenemia, and insulin resistance.

Assessment of biomarkers for the non-invasive diagnosis of male infertility

Infertility is a health issue that affects over half a million Canadian of childbearing age. Half of these cases are related to male reproductive dysfunctions. While semen analysis provides information about some causes of male infertility, about thirty percent of these cases remains unexplained. In this context, the main goal of our project is to assess the potential of target molecules, which are secreted from the internal organs of the male reproductive system into the seminal plasma, as biomarkers for the non-invasive diagnosis of infertility.