This project will focus on the design, fabrication and testing of an annular array-based histotripsy transducer that will improve the combined ultrasound imaging and therapy endoscopic device currently in development at Daxsonics. Histotripsy is a method of focusing high intensity ultrasound waves to liquify tissue and is a promising new method of accurately removing tumors with much less damage to surrounding tissue than current methods. This device will be part of a surgical suite for minimally invasive neurosurgery, enabling removal of tumors with extremely high precision.
The project involves the development of a power amplifier for driving therapeutic ultrasound transducers such as those used in treating cancer and inducing blood coagulation. In particular, the design will make use of a unconventional amplifier topology, class E/F, and advanced GaN FET technology in order to maximize amplifier efficiency. High efficiency amplifiers are important to reduce the number of fans and heat sinks needed in the ultrasound console, allowing the system to be cooler, lighter, lower cost and more portable.
It is the aim of this internship to develop and perform cost-analysis on a set of manufacturing protocols for batch production of high frequency annular ultrasound imaging arrays. To our knowledge this would represent the first time that such arrays have designed for high-volume (2000/wk) production, making the project highly novel. Once the process is developed, five of the arrays will be prototyped and their performance evaluated. The intern will test and improve on the manufacturing protocol and analyze the process for cost, yield and inter-device uniformity.
This project will develop a low cost, high-frequency ultrasonic scanner that will provide two dimensional images of small animals. The system is targeted at the academic researchers and small biotechnology firms that use small animals for basic science research or testing of therapeutics. A novel scanning mechanism, currently at prototype stage will be developed and integrated into a full imaging system by the applicant.
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