Signal profiling of 5-HT2A receptors to develop new biased ligands

G protein coupled receptors (GCPRs) are proteins found at the surface of cells are responsible for activating numerous intracellular signaling pathways and thus are involved in regulating about every physiological response. Activation of GPCRs occurs via a diverse array of stimuli as varied as photons, lipids, ions, small hormone or neurotransmitters through to larger peptidic and protein molecules. Currently, GPCRs are currently the target of up to 40% of marketed drugs.

Psilocybin as a potential treatment for social behavior (SB) disorders

Impaired empathy and social skills lead to severe social consequences and influence the development and treatment of several psychiatric disorders. Furthermore, empathy has been shown to play a crucial role in moral and prosocial behavior. Recently, a revamped interest for psychedelic compounds has invested the medical research community. For instance, psilocybin is a psychedelic compound which has been demonstrated to safely relieve depression in treatment-resistant depressive patients when used in a controlled setting.

Therapeutic efficacy of tryptamine analogues in a PC12 Cell as a model of depression via assessment of neurite outgrowth and enhanced cellular viability

There is a growing body of evidence that certain combinations of bioactives derived from natural source products may have potent effect on neuritogenesis and foster neuronal cell viability. The effect of neuron plasticity suggests there are potential treatments of major neurodegenerative and psychiatric conditions.