The aquaculture industry is constantly growing worldwide. Vast arrays of fish species are farmed in freshwater, brackish, and marine systems. In farms, fish reach high-population densities, which facilitates the outbreaks of infectious diseases. This is a big challenge for the aquaculture industry, particularly in the case of viral pathogens because there are few, if any, efficacious treatments against emergent and re-emergent fish viruses. Piscine orthoreovirus (PRV) is an emerging viral pathogen that causes high economic losses in the salmon farming industry.