Mechanism of CoVID-19 induced hyperinflammation

This Mitacs-NSERC COVID-19 joint initiative is to investigate the mechanism of COVID-19 inducing hyperinflammation and cytokine storm. COVID-19 infected cells cause injury that triggers immune cells to release inflammatory cytokines. The partnership with Encyt Technologies Inc. and PI will use established immune macrophage cell lines to identify the molecular mechanism of hyperinflammation induced by COVID-19 ACE2/Ang-(1-7)/Mas GPCR platform in triggering the processes associated with this cytokine storm.