Development and Evaluation of a Life Threatening Infections Point-of-Care Triage Test for the Fionet System - Year two

Febrile syndromes are among the most common causes of global illness accounting for approximately two billion episodes annually. However, most infections are self-limited and only rarely do they progress to critical illness. Our current inability to rapidly identify the small proportion of individuals who will progress to life-threatening infections (LTIs) is a major barrier to effective triage and precision management of serious infections. Our research has identified biomarkers with high diagnostic accuracy for LTIs.

Development and Evaluation of a Life Threatening Infections Point-of-Care Triage Test for the Fionet System

Febrile syndromes are among the most common causes of global illness accounting for approximately two billion episodes annually. However, most infections are self-limited and only rarely do they progress to critical illness. Our current inability to rapidly identify the small proportion of individuals who will progress to life-threatening infections (LTIs) is a major barrier to effective triage and precision management of serious infections. Our research has identified biomarkers with high diagnostic accuracy for LTIs.

Development and Evaluation of a Life Threatening Illness Point-of-Care Triage Test for the Fionet System

Building on our previous research and POC test prototype development, our goals for the project are to: 1) to confirm and further validate the association of altered levels of endothelial biomarkers with disease severity and mortality outcomes from LTIs in large patient populations in two settings, and 2) develop a rapid POC triage test for their detection at the bedside.

Identification of a biomarker panel of life-threatening infectious disease

Many individuals acquire infections each year, yet few progress to critical illness. The current inability to identify the proportion of individuals who will progress to life-threatening illness is a major impediment to effective management of infectious disease. Using malaria as a model, the aim of the project is to identify and validate a panel of biomarkers in blood that reliably detects individuals at risk of lifethreatening  disease.