A novel cell-pairing microchip for transcriptional profiling

The proposed initiative is different from conventional small molecules or biologics therapies. The living “drugs” are patients’ own immune cells. However, due to factors, such as age, and genetic differences between individuals, there is no magic “one treatment for all patients”. Intrinsic interpatient heterogeneity requires “personalized immune-therapy”. We have to adopt a “quality control” when we re-engineer immune-cells.

Probabilistic based Ultra-low Supply Voltage Noise Tolerant Circuits and Systems Design

As very large scale integrated circuit (VLSI) technology progresses, power consumption and power density of VLSI circuits increase when design complexity and transistor density increase. Low-power design becomes a major design challenge. Lowering the supply voltage is one of the most efficient ways to save power because power consumption is proportional to the square of supply voltage. Electronic devices are expected to operate at much a lower supply voltage than traditional designs, which is very useful for portable electronics and biomedical implants.

Self-powered nasal wearable sensor for diagnosis of Coronavirus 2019

Corona Virus 19 creates adverse effects on the global health system leading to economic crisis. Although trials to develop vaccines are underway, it would take a while for the general public. Wearable sensors have been receiving increased attention toward monitoring the wearer’s well-being and playing a significant role in the healthcare industry. The upper respiratory tract is the first site for hosting and transmission of COVID infection. Therefore, developing a wearable nasal sensor will achieve in-home continuous monitoring of virus in the nasal cavity.

Developing low-intensity pulsed ultrasound circuits to enhance cellulosic bioethanol yield for renewable energy

As the world finite supply of fossil fuels diminishes, viable alternatives are needed to empower the transportation, heating, and industrial needs of modern civilization. Lignocellulosic ethanol promises a means to transform abundant plant wastes into an energy-dense, carbon-neutral liquid combustible, compatible with current infrastructure. Unlike the first-generation biofuels derived from corn or sugarcane, lignocellulosic ethanol does not infringe on food production, although extra steps are needed to convert bulk cellulose into simple sugars suitable for fermentation.

Portable Device for COVID-19 Nucleic Acid Tests

We have seen the recent surge of COVID-19 because we cannot afford another massive shut-down. A portable and timely detection device for the COVID-19 nucleic test is more desirable. In this proposal, we propose to develop an impedance-based nucleic acid testing device. Our LOC devices are low cost, user friendly alternatives to centralized lab tests. By partnering with Hidaca Ltd., our ultimate goal is to have this made-in-Canada technology available on the market as soon as possible to benefit Canadians and the Canadian economy.

Design Energy Harvesting Circuit and its System-on-Chip Implementation

We have seen the acceleration of global warming in recent years. Green-energy powered electronic devices are more desirable. In this proposal, we propose to develop an energy harvesting circuit and implement it on a system-on-chip. The design goals are low-cost, user-friendly, and portable. By partnering with Hidaca Ltd., our ultimate goal is to have this made-in-Canada technology available on the market as soon as possible to benefit Canadians and the global population.

Ex-vivo Device for Screening the Efficacy of COVID-19 Vaccines and Producing Antibodies

COVID-19 has significantly impacted the health of the global population. Although timely detection and isolation are important, vaccination is probably more effective in fighting against COVID-19. Our proposed ex-vivo can help the validation of the COVID-19 vaccine and produce antibodies for COVID-19. The benefit to the Canadian community and the industry partner is palpable.

Portable Low-cost Fast Impedance-based Point-of-care Diagnostic Device for COVID-19

COVID-19 has significantly impacted the world. Nucleic acid, CT, and fever tests are standard tests, but they suffer from various limitations. For instance, CT requires large & expensive equipment. The nucleic acid test is not portable and takes at least two days. As sensor technologies get more advanced, a portable, low-cost and fast diagnosis COVID-19 device becomes more desirable. Our proposed impedance-based device takes 2 minutes to check lung infection and takes 20 minutes to obtain antibody results. The benefits to patients are apparent, especially low- and mid-income countries.

Low-cost Portable Impedance-based Biosensor for Tuberculosis Test

Tuberculosis (TB) is one of the deadly diseases in low- and mid-income countries. Currently, X-ray and TB culture tests are standard tests, but they suffer from various limitations. For instance, an X-ray requires large & expensive equipment while TB culture test takes a long time. As sensor technologies get more advanced, portable and low-cost diagnosis TB test assays become more desirable. Our proposed palm-size device required a urine sample of 40 mL, and it takes 20 to 30 minutes to obtain results. The battery-powered device is ease-of-use and costs less than $2 for each test.

Deep Learning Method for Micromotion Detection and Mental Health Disease Diagnosis

Over the past few decades, mental disorders (e.g., depressive and anxiety) have become a significant medical burden for people of all ages. According to the survey performed by the World Health Organization (WHO), at least one out of ten people in the world suffers from mental health diseases (i.e., mental disorders, neurological disorders and addition). Many factors, such as heredity, work pressure and aging, can attribute to these disorders and degradations. However, some of these mental health diseases are preventable and treatable.

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