Raman spectroscopy is a non-destructive laser-based optical technique that provides information on the molecular composition of biological tissue. Using this technique, it is possible to distinguish different types of tissue and use this information to develop prognostic tests to evaluate, for example, how a patient will respond to a specific therapy.
The research objectives are to better understand the limitations of a new particle sizing system in terms of accuracy on particle size, of accuracy on size distribution, of accuracy on particle concentration and finally of size dynamic range. During the research project, the sources of the limitations will be identified and improvements to the technology will be proposed. State-of-the-art equipment for the generation of particles with known sizes and concentrations available at the University of Alberta will be used for the characterization of the technology.
When light interacts with matter, different effects may take place, depending on the particular characteristics of both light and matter. The result of this interaction, typically a quantitative change in the characteristics of the light (i.e., intensity, wavelength, phase), can be used to measure the presence of a particular specimen of interest. Specifically, Surface-enhanced Raman Scattering (SERS) has demonstrated to be able to detect accurately very low concentrations of chemical species.