Evaluation of corticosteroid-releasing nano- and micro-particles for pain management in osteoarthritis

Osteoarthritis is a progressive joint disease that causes pain and stiffness, resulting in a decrease in quality of life for patients. Treatment include intra-articular administration of crystalline corticosteroids or hyaluronate. Intra-articular corticosteroids, due to the large doses required, short residence time in the joint, and crystalline structure, are associated with cartilage damage and a short duration of action requiring multiple injections.

Evaluation of corticosteroid-releasing formulations to suppress implant device- related foreign body reactions and fibrosis

Implanted medical devices have dramatically improved the lives of millions of patients worldwide. However, in many cases, the body’s immune system rejects these devices and encapsulates the implant in fibrous scar tissue. This reaction is most detrimental to sensors for continuous monitoring and treatment of chronic conditions such as diabetes and those of the central nervous system. Device functionality is usually severely limited and risky additional surgeries for implant removal and reinsertion are required.

Biomaterials for the reduction of bacterial adhesion and biofilm formation

Stents are tubes placed between the kidney and the bladder which prevent blockages which might otherwise damage the kidney. Introducing foreign material into this system allows a platform for bacteria to exist and which will potentially cause infections. These are very common. We propose modifying the surfaces of the materials used in stents to make them “non-stick” to prevent bacteria attaching and then causing infections. We can test this in the laboratory and wish to test different types of material under different conditions which mimic the clinical environment.