The project addresses urgent and clinically-relevant questions related to COVID-19, which causes in some patients life-threatening respiratory distress, septic shock and organ failures. Patients in intensive care units were found to have significantly higher levels of high mobility group box 1 (HMGB1) than patients with milder symptoms. HMGB1 is a protein normally found in the cell nucleus that is released outside the cell under inflammatory conditions such as viral infections.
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