Mathematical and Computational Analysis of Shape from MR Images for the Study of Multiple Sclerosis

Everyday, three Canadians are diagnosed with multiple sclerosis (MS), which affects the brain and spinal cord, causing lesions and atrophy. MS produces deformation in the central nervous system, causing disability and in extreme cases, death. In the human brain, one of the many structures affected by MS is the corpus collosum. The corpus collosum contains millions of nerve bundles which connect the two brain hemispheres by acting as a bridge for the inter-hemispheric communication. Deformation of the corpus collosum, therefore, causes disruption of nerve impulses along the nerve fibres.