Synthesis and Evaluation of Reversible Covalent-Binding AntiCancer Drugs

Designing new anticancer agents using structure based drug design and the 3D structure of the biological targetis becoming an increasingly important field of study. The main objective of this project is to develop and identifyanticancer drug candidate(s) for advanced preclinical testing, with the end goal of identifying drug candidatessuitable for clinical trials and commercialization. Currently, we have synthesized several novel drug candidatesdesigned to mitigate the increased toxicological effects observed in a significant proportion of patients receivingcurrent therapies.

Design and Development of the Smart Friction Pendulum System (FPS) for High-Rise Buildings to cope with seismic loads

Buildings are vulnerable to moderate and powerful earthquakes. In order to keep their functionality during and after the seismic events, structural control systems are the promising candidates to be embedded in the buildings in which they dissipate the energy towards the building and separates the movements between the soil and the infrastructure. One of the common systems for this protection is the friction pendulum system (FPS), but it has the disadvantage of losing position once an earthquake happens.

Software development for beam-type structures' reliability analysis

Reliability analysis of structures is crucial to ensure efficient operations in industrial assets. Nowadays, industries benefit from condition monitoring (CM) equipment to evaluate their products' health. Current commercial reliability software can not accurately analyze the reliability of structures under time-varying conditions. The intern has previously developed an algorithm for accurate reliability analysis of different structures. We have also validated that algorithm for bearings under time-varying working conditions.

A Compact Attenuated Total Internal Reflection Stage for Rapid Materials Testing

Light is a powerful sensing tool that humans are very familiar with. We are, however, only sensitive to a visible light. Much more can be learned from other types of light. Terahertz light is very low energy light that allows very sensitive non-invasive measurements to be made on many types of samples including biological and polymers. This makes it a compelling tool and currently there is exponential growth in Terahertz light technologies.

Distributed Fault-tolerant Drone Network Design

Unmanned Aerial Vehicles (UAV) or drones have numerous applications in different industries. However, drones have limitations such as short flight time, limited flight range, and navigational inaccuracy in regions with unreliable GPS signal. To mitigate these limitations, using a group of drones to cooperatively perform the mission is proposed. The resulting parallel operation increases the efficiency and reduces the operational time. In addition, we propose a cooperative localization to navigate the group of UAVs as a back-up for GPS navigation.

Demonstration of Dissipative coupling from an Electrical-Magnetic friction coupled pendulum system

Laboratory pedagogy is considered absolutely critical for physics and engineering education ranging from high school to university. Among all universities worldwide, a well-known first-year physics experiment demonstration is a spring-coupled pendulums system. It demonstrates the coherent coupling; the underlying physics is reflected from classical mechanics to advanced quantum systems. It has excellent application from a tuned mass damper that reduced the unwanted vibration in skyscrapers and precision machining to data transformation of a quantum computer.

Development of an embedded piezoelectric sensor for bearing fault detection

Rolling element bearings act as the heart of rotating machines. Any imperfection in their condition can lead to an abrupt failure which can be catastrophic. For more than two decades, implementing sensors for condition monitoring of bearings has been beneficial in preventing abrupt failure and fault detection. These sensors require a noise-free atmosphere to have optimal performance, however, noise and vibration from other machines are an unpreventable part of an industrial environment.

Improvement of a Portable Assistive Device Concept for Hand Rehabilitation

As the number of patients with stroke and Parkinson's Disease (PD) increases, it is essential to obtain treatment progress data efficiently for the home rehabilitation. For the therapy of hand disabilities, a system is required to collect data, process and control hand motions during rehabilitation. Current rehabilitation devices that are available in the market are costly and not portable. Existing hand training devices use contact-based sensing approaches that are expensive and inaccurate.

A model retrieval system for efficient bolus shaping

Bolus covers patient’s skins to correct varying surface contours for desired dose distribution in cancer care. The existing method of bolus shaping is a manual process by cutting the bolus material into 2D pieces and wrapping the pieces on the targeted body area, which is inaccuracy and time-consuming. An accurate and efficient bolus shaping method is proposed to increase the bolus shaping accuracy and reduce air gaps by applying a 3D-2D-3D process. In order to improve the efficiency, a model retrieval system will be developed based on feature extracting and image-based matching methods.

Design improvement and prototyping of an upper limb rehabilitation device

Upper limb rehabilitation devices mirror the skeletal structure of patients’ limbs and moves patients’ arms for recovery in rehabilitation exercises. Existing rehabilitation devices in the market have problems of adaptability and portability, which cannot meet different requirements of rehabilitation. This project will improve the design and build a prototype the device. The detail design will be improved in dimensions and specifications based on relation of design parameters and functions. The device prototype will be made by 3D printing.