Depression is a leading cause of disability worldwide, yet only one third of patients with depression receive care. This is because the traditional in-person format of mental health care delivery can be inaccessible, inefficient, and expensive. Electronic cognitive behavioural therapy (e-CBT) has been shown to be an effective solution to expand care access, efficiency, and affordability. Combining depression-based e-CBT with artificial intelligence, this study aims to develop an effective decision-making model that matches an individual’s needs with the right amount of care.