Clinical translation of carbohydrate nanomedicines for gene therapy

Nowadays, we are facing a lifetime risk to acquire cancer. Gene therapy has emerged as a promising and alternative approach for the treatment of several types of cancers as compared to chemo/radio therapy. For introducing these genes into the human body, a vehicle is necessary to protect them from degradation in the physiological environment and also to ensure that the new genes are directed to the desire sites. Sugar polymers are of great interest because they are able to mimic natural glycan’s in our body, ensuring its safety and biocompatibility.

Chitosan-derivatives as a platform for drug and protein delivery

Triozan™ is a safe, biodegradable and biocompatible hydrophilic and highly quaternized biopolymer with advantageous physicochemical properties that enables an efficient encapsulation and protection of drug molecules against degradation while simultaneously maintaining therapeutic integrity. We propose to encapsulate three drug candidates into nanogels formed from Triozan to enhance their therapeutic application and overcome multiple barriers such as multi-drug resistance phenomenon present in bacteria and in cancer cells as well as biological barriers such as the hematoencephalic barrier

Development of Chitosan-based Nanosparticles forLoading Non-water Soluble Medicine

Over 90% new drugs cannot be used in market or perform inefficiently because of their poor water-solubility. Delivery of non-water soluble medicine by using biodegradable carriers can solve the problem. This research work aims to develop N-trimethyl chitosan chloride (TMC)-based nanoparticles used as a drug carrier for delivering non-water soluble medicine to enhance the therapeutic efficiency. Two interns will be involved in this project. Collaborating with Ovensa Inc., we will produce TMC-based nanoparticles with suitable particle size and surface properties.

Designing quality control strategies to assess the self-assembly and biological stability of chitosan nanoparticles

In this grant, the consortium will develop new methods to characterize nanoparticles prepared with a proprietary polymer. This study will enable the fabrication and characterization of better performing nano-sized particles encapsulating therapeutic molecules, commonly called nanomedicines. This study will allow to monitor how the polymers self-assemble into nanoobjects under different conditions, and to study how the nanoparticles perform in various environments. The project will develop and validate methods to streamline the development of nanoparticles with a variety of characteristics.