Supercritical carbon dioxide processing for the production and standardization of isoflavone extracts from red clover

This project aims at investigating the use of the eco-friendly solvent, supercritical carbon dioxide (SCCO2), alone or in combination with ethanol and water, to obtain extracts rich in isoflavones from red clover plant. Firstly, SCCO2 will be used for obtaining extracts containing a high concentration of isoflavones. Then, SCCO2 will be applied to the extracts at different experimental conditions to concentrate and obtain fractions with a higher isoflavone purity.

Molecular modeling module of the pharmaceutical platform technology

Pharmaceutical platform technology (PPT) was invented by Sinoveda Inc., the partner organization, to accomplish the tasks of identification, purification, and activity determination for the active ingredients of natural herbal remedies, with the goal of developing and optimizing the remedies. However, two issues remain to be tackled in the PPT process: first, there is as yet no systematic approach to take advantage of the properties of the ingredients of herbs; and second, there is a lack of appropriate methods to consistently understand their effects.

Calcium supplements, elemental bioavailability, and uptake by bone (Part 2)

There is an increasing number and variety of calcium supplements being made available to the Canadian public, often making claims regarding improved action over competitor products. The purpose of this project is to evaluate the effects of drugs and nutraceuticals upon bone health, particularly if they contain elements (such as calcium) which incorporate into newly mineralizing bone.

The role of novel red yeast rice formulations to modulate lipid metabolism and reduce dyslipidemia and vascular disease in the JCR:LA-cp rat.

The primary objective of this MITACS study is to utilize a novel animal model with high blood lipids to assess the potential lipid lowering efficacy of red yeast formulations developed by SinoVeda Canada Inc. The intestine is the first-pass organ for the metabolism of dietary lipids and has an important role in whole body cholesterol homeostasis.  While the intestine is known predominantly to absorb and secrete cholesterol and contributes to faecal sterol removal, it has also been proposed to contribute to the regulation of plasma cholesterol concentration.  Funding from my NSERC Discovery