The anti-Helicobacter pylori properties and mechanism of action of probiotic Lactobacilli secretomes

Helicobacter pylori (HP) is a bacterium that causes 65% of gastric ulcers and cancers worldwide. Current anti HP treatments often fail because the bacteria have become resistant and they have serious side effects. We are looking into using molecules produced by bacteria called Lactobacilli that are a natural component of the human gastro-intestinal flora to treat and/or prevent Helicobacter infections. The novelty of our approach is to focus on the molecules that Lactobacilli release (i.e. their secretions) and that could be administered to patients in a controlled and reliable manner. Using the released molecules also facilitates determining the mechanism of action. We have compares the secretions produced by 25 Lactobacilli for their anti-HP effects and have identified very active strains. We propose to determine their mechanisms of action and identify the nature of the active molecules. TO BE CONT'D

Intern: 
Samantha Whiteside
Faculty Supervisor: 
Carole Creuzenet
Province: 
Ontario
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Partner University: 
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