Bioprocessing strategies for enhanced production of heme in Escherichia coli

Ardra Inc. has sustainably produced many high-purity chemicals that are used for various flavor, perfume, and cosmetic applications. Combining industrial/business expertise provided by Ardra with academic/research skills provided by Dr. C. Perry Chou’s lab, we are aiming to effectively produce high-value heme compound using engineered E. coli host organism. Major efforts will be dedicated toward engineering of this bacterium by adopting synthetic biology, metabolic engineering, and bioprocessing strategies to facilitate large-scale bio-based production of heme. As a long-term goal, it will provide innovative strategies for the production of heme in a clean, sustainable, and cheap way. Lastly, it will enhance world biomass economy and biomanufacturing capacity, leading to the improvement in the quality of life.

Dragan Miscevic
Faculty Supervisor: 
Perry Chou
Partner University: