Brain changes after 1 year of treatment with an injectable antipsychotic in people with a first-episode psychosis.
The proposed project will explore variations in the whole brain after 1 year of treatment that may exist between those who are taking an injectable antipsychotic versus those who are taking an oral antipsychotic in a cohort of first-episode of psychosis. All patients are treated in a naturalistic, early intervention setting at the Douglas Institute in Montreal, Canada. Janssen will benefit from the proposed project as it will help determine the benefits, if any, for prescribing an injectable earlier on in treatment,
namely related to brain tissue change. Increased knowledge about the effects of using injectables earlier on in treatment is needed so that more clinicians would consider starting this type of treatment sooner in hope of achieving a better outcome for more people.