Cloud-based analysis platform for in-house DNA sequencing: plasmid validation

Biological manufacturers are now starting to make chemicals and biological products (like proteins) by growing large amounts of microorganisms like bacteria or algae. One major quality control step in the manufacturing process is to check the genetic sequences of these microorganisms because they often not correctly made. This is due to the biological method for manipulating the sequences is not perfect. To check that the genetic sequences are correct, manufacturers typically send samples for DNA sequencing at international service providers. Recent advances in DNA-sequencing technology allow for this to be done in-house, but it requires specialized computers and software skills. We are therefore developing an easy-to-use web application for advanced biological manufacturers to verify genetic sequences in-house, which will significantly speed up the manufacturing process.

Daniel Giguere
Faculty Supervisor: 
Gregory Gloor