Correlation of Coronary and Myocardial Strain Profiles for Cardiac Resynchronization Therapy

Cardia Resynchronization Therapy (CRT) is aq pacing therapy used to reduce symptoms and mortality in patients with heart failure. It delivers a specialized pacing lead to the left ventricle (LV) through the coronary veins to re-synchronize the contraction of the heart when it has become delayed or desynchronous. However its benefit has proved to be dependent on the placement of this lead to regions where mechanical delay is maximal and does not have underlying myocardial scar. Medtronic Inc. is developing a software (called CardioGUIDE) aimed at automated segmentation of the coronay veins and analysis of their corresponding strain profile from intra-procedural cine fluoroscopy. This sofgtware may provide an intuitive road-map for the placement of the LV lead to optimal targets/ The aim of this proposal is to develop a validation pipeline for the testring of CardioGUIDE against the gold standard of cardiovascular MRI. Validation will be perfmormed in 60 patients receiving both Cardio GUIDE analysis and comprehensive cardiovascular MRI Imaging. This research will allow for clinical validation of this novel CRT lead navigation system and greatly assist in its commercialization asnd clinical dissemination.

Alessandro Satriano
Faculty Supervisor: 
Dr. James White
Project Year: