Developing implantable scaffold for bone regeneration with healing enhancement by local drug delivery and sustained drug release

Over 3 million Canadian suffer from bone disease resulted from trauma, tumor removal and cancer and the number increasing with aging population every year. We plan to use hydrogels to create bioactive scaffold using 3D bioprinting extrusion method with potential for local drug loading and slow drug release for bone regeneration. We develop bioinks with proper mechanical strength and fidelity to keep the shape of the scaffold. I this work with incorporate bone growth factors to accelerate repair of bone defects. Encapsulation growth factors in nanoparticles gives us the opportunity for sustained and prolongation of drug release in a control manner which results in enhancement of bone regeneration and healing.

Nafiseh Moghimi
Faculty Supervisor: 
Mohammad Kohandel
Partner University: