Developing methods to isolate regulatory innate lymphocytes
Enhancing tissue homeostasis and immune tolerance mechanisms is pivotal for the development of new therapeutic approaches for transplantation and autoimmunity. This proposal is focused on harnessing newly discovered types of lymphocytes that regulates immune responses in cell-based immunotherapies. We are developing methods to isolate and expand these newly identified regulatory lymphocytes and are assessing their ability to prevent immune-mediated tissue damage. The goal of these studies being to use these cells in immune-based therapies for transplantation.