Glioblastoma (GBM) is the most common and deadly cancer arising from the adult brain. There is no effective treatment and a vital need for new, accurate biological models to understand the character and reveal new possible therapeutic strategies. The mouse has long been used to model human GBM, but the very small anatomy creates many limitations. Hera Biolabs has created the SRG rat with brain volume about 5 times those of mice. This proposed study will evaluate the growth of human GBM in SRG rats and the treatment response in this new model. We expect this study will yield cost-effective and accurate new resources to benefit GBM research and the greater neuro-oncology community.