Development and preclinical evaluation of R-Sulforaphane-based therapeutics in treatment of chronic kidney disease
R-Sulforaphane (R-SFN) is a naturally occurring phytochemical that can be found in most of cruciferous vegetables, such as broccoli and kale. R-SFN has been shown in many research studies holding therapeutic promise for many chronic diseases. We propose to develop more advanced methodologies to product, purify and formulate R-SFN. We also propose to evaluate the therapeutic effect and safety profile of R-SFN in treating chronic kidney disease (CKD) in a rat model. If successful, the new developed product will benefit millions of patients who are suffering CKD by extending their life span and improving their life quality.