Development of a high-throughput cardiac differentiation assay to elucidate placental trophoblast stem cell signaling during heart development

Heart defects that affect newborns are often correlated to a disfunction in the placenta, although we currently do not fully understand why this occurs. Our objective is to develop a screening platform that uses a model of heart development to understand how cells of the placenta communicate with to cells in the developing heart. This improved understanding will aid in developing therapies for congenital heart defects. The partner organization, which is our start-up company Cytinnov, will employ their proprietary process to develop this platform and benefit from having this data as a case study to recruit additional future customers.

Derek Toms
Faculty Supervisor: 
Myriam Hemberger
Partner University: