Development of a multifunctional in situ-forming scaffold with antimicrobial activity for treatment of complex wounds
Pressure ulcer is one of the top five leading causes for re-hospitalization of spinal cord injured patients. In general, there are three main difficulties associated with treating these ulcers: 1) Presence of cavities and tunnels which makes it difficult to treat with conventional regimens, 2) A high chance of infection and, 3) Susceptibility to weight-bearing pressure on bony areas of the body. To address these unmet challenges, we propose to manufacture a novel wound care product consisting a fibrous scaffold loaded with antibacterial silver nanoparticles embedded within a liquid matrix.
This composite is ideally a flowable scaffold that can improve the healing outcome of wounds by filling up deep wounds of varying depths and shapes from the bottom up, preventing the growth of bacteria, and increasing physical strength of the healed wound. TO BE CONT'D