Development of probiotic formulation to alleviate gut dysbiosis related to antimicrobial activity of several classes of psychotropic chemicals
Several classes of psychotropic compounds have been increasingly shown to possess antimicrobial properties with possible implication in microbiota-gut-brain axis. For instance, sertraline and paroxetine are efflux inhibitors in bacteria cell walls and are effective on gram-positive bacteria such as Enterococcus and Staphylococcus. Therefore, a comprehensive assessment of the antimicrobial effect of these chemicals on gut commensal bacteria and consumed probiotics will provide critical insight for the design of robust new nutraceuticals. This project will provide essential data prerequisite to the potential application of probiotics for prevention of gut dysbiosis, specifically in response to psychotropic chemicals..