Effects of a novel probiotic supplement on bone health in postmenopausal women
Menopause is the natural cessation of a woman’s menstrual cycle. During this transition, low levels of estrogen and associated pro-inflammatory state stimulates a rapid decline in bone tissue which may ultimately increase the risk of fragility fractures. Prevention strategies are warranted to maintain bone mineral density and a strong skeleton after menopause and use of probiotics may serve as a promising approach. Probiotics may modulate bone via regulation of the gut microbiome and subsequent anti-inflammatory pathways in a bacterial strain-specific manner. The objective of this study is to examine the effects of a novel probiotic supplement on attenuating a loss of BMD, modulating fracture risk, and improving markers of bone cell activity and inflammation compared to no intervention in postmenopausal women.