Efficacy of CB1R inverse agonists for enhancing insulin secretion in mouse and human islets, ex vivo, and for preventing cytokine-induced ?-cell death in human islets

Inversago and CR-CHUM will collaborate to evaluate new generation Cannabinoid-1 receptor (CB1) blockers for the treatment and/or prevention of type-1 and type-2 diabetes. Previous generations of CB1 blockers have shown their promise in treating several features of the metabolic syndrome, including obesity, type-2 diabetes and liver diseases. However, they were plagued with important psychiatric adverse effects which eventually caused the termination of all development and commercial efforts. Inversago’s drug candidates have shown high potency towards the same target (CB1 receptors) but are not providing brain exposure, and therefore should not provoke psychiatric side effects.
Recent research in the field of Type-1 diabetes has suggested that CB1 receptors located in pancreatic beta cells could be linked to improved insulin production and secretion, as well as beta-cell proliferation. As such, it is of interest to evaluate Inversago’s candidates in the research laboratory of the diabetes world expert Prof. Marc Prentki to evaluate their potential to treat type-1 diabetes.

Anindya Ghosh
Faculty Supervisor: 
Marc Prentki
Partner University: