Engineered Polymers for Nucleic Acid Therapies: Phase 2

Nucleic acids such as DNA and RNA offer exceptional opportunities to fight against cancers. To use nucleic acids effectively in a clinical setting, one needs to use effective delivery vehicles that can deliver the nucleic acids into the diseased cells. This project will develop effective delivery systems for this purpose. The delivery systems will be used to deliver RNA based therapeutic agents in 2 diseases, namely in solid cancers such as breast/lung cancers and in hematological cancers. We will develop specific drugs against these diseases and test them in culture and animal models of the diseases. Successful completion of this project will advance the therapies towards clinical testing.

Amarnath Praphakar Rajendran;Daniel Nisekar
Faculty Supervisor: 
Hasan Uludag
Partner University: