Enhancement of Canine Adipose Tissue-Derived Mesenchymal Stromal Cells Immune-Modulatory Properties and In Vivo Feasibility Testing in Elbow Dysplasia Patients
Osteoarthritis is a major cause of disability in dogs. Today, the therapeutic role of mesenchymal stromal cells (MSCs) as a potential treatment for immune and inflammatory disorders is well-defined. We are interested in exploring the immune-modulatory property of canine MSCs with the aim of exploiting it as a potential therapy in dogs with Elbow Dysplasia. This foundational work will support future funding applications to conduct a randomized clinical trial (RCT) to evaluate the effectiveness of the treatment. This project will provide a baseline for a long-term research program to discover new drugs and/or cell-based products that can develop novel treatment strategies to help osteoarthritis patients.