Evaluation of neuro-protective effects of novel water-soluble formulation of Ashwagandha root extract alone and in combination with water-soluble Ubisol Q10 using in vitro and in vivo models of Parkinson’s disease

There is an increase in brain diseases like Alzheimer’s and Parkinson’s diseases as the number of aged individuals is increasing. Currently there is no treatment available that can halt the progression of these diseases. Previous work has shown that a natural compound CoQ10 can prevent brain cell death. Similarly an Ayurvedic Herbal extract, Ashwagandh Root Extract has also shown promising results in some studies. In the present research project we will prepare a novel water-soluble formulation of CoQ10 and Ashwagandha Extract using a patented technology of Nextremedies Inc. We will test this novel formula in cellular (in petri dishes) and animal models of Parkinson’s disease to find out if it can protect brain cells and halt the progression of Parkinson’s disease. Successful completion of this project will lead to the development of a natural neutraceutical formula that can be used to treat Parkinson’s disease.

Intern: 
Caleb Vegh
Sezen Eren
Faculty Supervisor: 
Siyaram Pandey
Province: 
Ontario
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Partner University: 
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