Evaluation of Tristetraprolin in a Lipopolysaccharide-induced mouse model of fetal loss

Maternal complications such as miscarriage or fetal loss are important reproductive issues that can affect up to 30% of pregnant women worldwide. While these complications are worldwide health problems, their mechanisms are not yet clear. Using a well-established mouse model of fetal loss, our goal is to detect localization patterns of important genes that may play a role in fetal loss. We also aim to detect and measure expression levels of these genes in the same samples as well. We anticipate to ascertain varying degrees of cellular localization of our genes of interest with a differing pattern between our control and treated (lipopolysaccharide) groups. From this project, we aim to elucidate how some important genes may interact with each other and potentially contribute to fetal loss.

Kasra Khalaj
Faculty Supervisor: 
Chandrakant Tayade
Partner University: 
FIOCRUZ - Aggeu Magalhaes Research Center