Formulation of Cationic Peptides by Hyperbranched Polyglycerols for the Treatment of Chronic Rhinosinusitis
Chronic rhinosinusitis is a common condition in which the cavities in the nasal channel become inflamed and swollen. This condition interferes with drainage and causes mucus to build up. Delivery of the positively charged proteins containing short chains locally to the nasal area can be used for the treatment of this problem. This proposal suggests synthesis and characterization of negatively charged polymeric systems with specific modifications to bind to these proteins and stabilize them. This study is followed by investigation of the capability of the polymeric carrier to bind to the proteins and quantification of the bound amount. It will further continue by biological assessment of the designed system on the disease condition.