Generation and characterization of novel small molecule protein degraders in oncology

Many patients who initially respond well to highly efficacious chemotherapy eventually develop resistance and relapse despite continued treatment. These cancers acquire drug resistance to current therapies through various mechanisms such as the acquisition of mutations for example. Furthermore, some promising targets that play a crucial role in the progression of cancer have been deemed undruggable using current methods. The proposed project aims at synthesizing novel drugs based on a new design to target three proteins for degradation, located in different cellular compartments with their function well characterized in contributing to cancer. The knowledge gained from the project will allow the nomination of lead compounds that will be further developed by Paraza Pharma Inc. in the future as successful drug candidates.

Intern: 
Prashant Deore
Xiaolei Zhu
Koilpitchai Sivamuthuraman
Faculty Supervisor: 
Patrick Gunning
Province: 
Ontario
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Partner University: 
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