Highly Sensitive and Specific Detection of Aflatoxin B1 Implementing Aptamers and Gold Nanoparticle Localized Surface Plasmon Resonance

 

Rapid diagnostic tools represent a significant growth industry in agriculture. Current antibody based approaches have implicit limitations due to the cost and performance of the antibodies. The use of single stranded DNA (aptamers) as mimics of antibodies has the potential
to overcome many of these constraints. A key disadvantage to the use of aptamers is that they bind with lower affinity to their targets than antibodies. This means that we need to develop detection platforms that have a higher level of sensitivity than current antibody
detection methods. Dr. Mittler is a global leader in the development of detection methods based on optical properties of immobilized gold nano‐particles and evanescent wave analysis. This project represents an opportunity to apply her discovery efforts to an applied commercial opportunity.
Intern: 
Asad Rezaee
Faculty Supervisor: 
Dr. Silvia Mittler
Province: 
Ontario
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