This Mitacs proposal tackles several outstanding issues that must be addressed to complete development of a widely applicable pipeline for quantitative analysis of 3D facial shape in medicine. Here, we focus on specific applications of imaging pipelines in genetic syndrome diagnosis and facial surgery visualization and planning. The fellows will develop (a) cutting edge, deep learning models of 3D facial shape variation, (b) optimal strategies for defining boundaries between regions, (c) methods to infer high resolution skin color and texture from low resolution images, (d) and models that integrate 3D facial shape data with discrete and preference data for various purposes.