Investigating the mechanistic links between cannabinoid and pain-related gene variants and functional measures of musculoskeletal pain

Pain is a combination of mental, physical and social factors. This makes it difficult to understand and even more difficult to treat. Chronic pain is unique to the individual, and to treat it effectively requires a better understanding of how pain is generated in each person. The goal of this study is to describe the relationships between inherited genes and the factors that affect pain, recovery, and people’s response to medication. The first phase of this study has 2 aims. The first aim is to describe the relationship between genes, pain, and recovery time. The second aim is to see if there are any differences between the drugs that people were prescribed and the ones that are recommended based on their genes. The second phase of this study is to look at the effects of cannabis medications on pain in the context of the underlying genes. This study will not only help to refine the use of gene-based strategies for drug prescription, but it will increase our understanding of how to prescribe cannabis medications.

Intern: 
Joshua Lee
Faculty Supervisor: 
David Walton
Province: 
Ontario
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