Investigation of the solubility and tissue distribution of cannabinoids
Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), two main phytocannabinoids from cannabis, have demonstrated biological effects and potential therapeutic uses. However, their functionality when consumed orally could be limited due to poor water solubility and low utilization rate in human body. To make the cannabinoids more soluble, liquid formulations are being developed using food-grade oils and/or phytoglycogen, a natural compound from non-GMO sweet corn. Furthermore, the tissue distribution of orally ingested cannabinoids is still unclear, so it will be evaluated in this project using an animal model. These formulations can improve the incorporation of cannabinoids in edible applications, and the understanding of cannabinoid tissue distribution will help developing medicinal products that are safer and more efficient.