Label-free Multiphoton Microscopy Imaging for Guiding the Surgery of Skin Basal Cell Carcinomas
Basal cell carcinoma (BCC) is the most common cancer type. Although it can be surgically removed, to confirm the clean removal by histology is time-consuming, which complicates the treatment and results in many incomplete removals. We propose to develop a special microscopy imaging platform that can image the skin tissue directly without sectioning and staining. This will enable detection of residual tumor cells by examining the excised fresh tissue samples on site during the surgery, providing immediate guidance for improving the treatment procedures. It will make the surgery fast, reduce patient pain and anxiety, and also help reduce cancer recurrence. These will enable the hospital to provide improved care for skin cancer patients. And it will also bring significant cost savings to the hospital and the Canadian healthcare system.