Long-Term Prevention of Catheter Infections using Chemical Coatings
Infections acquired through long-term catheter use are a major problem for nearly 20% of all patients. This project seeks to apply Econous Systems anti-fouling MEG-OH coating to biomedical plastic catheters to see if they prevent the 3 most common microbes: E. coli, C. Albicans and S. Aureus, from growing. This will initially involve in vitro testing using a flow-through model to simulate blood flow, monitoring first static and then dynamic microbe growth using fluorescence microscopy. In vivo testing will follow using rats as a preclinical model.