Long-Term Prevention of Catheter Infections using Chemical Coatings

Infections acquired through long-term catheter use are a major problem for nearly 20% of all patients. This project seeks to apply Econous Systems’ anti-fouling MEG-OH coating to biomedical plastic catheters to see if they prevent the 3 most common microbes: E. coli, C. Albicans and S. Aureus, from growing. This will initially involve in vitro testing using a flow-through model to simulate blood flow, monitoring first static and then dynamic microbe growth using fluorescence microscopy. In vivo testing will follow using rats as a preclinical model.

Intern: 
Michael Morozov
Faculty Supervisor: 
Benjamin Hatton
Province: 
Ontario
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