Mechanical characterization of phage-coated implants for the prevention and treatment of periprosthetic joint infections in high risk patients
Caused by planktonic and biofilm drug-resistant bacteria on implants, periprosthetic joint infections (PJI) is one of the most devastating complication in orthopedics and is in line with forecasted rise in joint replacement. From the perspectives of patients, surgeons, hospitals, and health care system, PJI thus present a great unmet medical need, resulting in high morbidity, and even mortality, among affected patients. Therefore, clinicians would find invaluable a technology with a potential to manage PJI on implants. With the rise of antimicrobial resistance (AMR), a new technology to prevent or treat PJI would be invaluable.