Multiomic characterization of stem cell derived extracellular vesicles for supporting the skin

Studies performed over the last 10 years or so have revealed that the primary power of human stem cells lies in what they produce and release or excrete, not the cells themselves; this includes growth factors, paracrine factors, peptides, extracellular vesicles (EVs), and most importantly, exosomes. This is good news, as it means we can potentially capture, preserve, and administer the biomolecular signals or ‘messages’ generated and released by stem cells without needing to transplant live stem cells into or onto someone to get the benefit or effect, avoiding potential immune rejection at the same time.How and why these nanosized biomolecular messages, defined in the literature as “exosomes” or EVs, are generated by stem cells, and how we might be able to control or influence their production, is only partially understood. Through in depth analysis of stem cell derived exosomes produced from umbilical cord derived stem cells following different triggers, we aim to better understand how to leverage the power of stem cells to support and repair the body, focusing initially on the skin.

Intern: 
Michelle Combe
Faculty Supervisor: 
Stanislav Sokolenko
Province: 
Nova Scotia
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