SRRM4 protein purification and antibody production
The SRRM4 gene has been recently identified as a key protein responsible for a subtype of highly aggressive prostate cancers, called neuroendocrine prostate cancer (NEPC). Detection of SRRM4 protein in patient tumor biopsies is therefore important to predict and diagnose NEPC, so that early and more effective therapeutic means can be in place. Unfortunately, there is no SRRM4 antibody currently available that can be used for pathological analyses. This project will join force of academic and industrial expertise to develop a SRRM4 antibody that can be used in clinic for NEPC diagnosis.