Synthesis and characterization of a new generation of bone targeting anabolic and anti-cancer prodrugs
This project is intended to discover new drugs to treat bone diseases. Getting drugs too bone is very difficult due to poor vascularization of bones and require high doses of a potent drug which can lead to unacceptable side effects. This project intends to design, synthesize and characterize novel “bone-targeting prodrugs” to treat osteoporosis, help repair bone fractures and injuries and to treat bone cancers. These prodrugs will bind selectively to bones and then slowly release the active drugs over days and weeks so as to provide enhanced efficacy and reduced side effects.