Synthesis of glycopolymers by in vacuo glycation

Sugars play many important roles in our bodies. For example, they provide a supporting environment around cells and are also involved numerous processes, including viral and bacterial infection. In addition to their natural existence, there is also interest in preparing sugar-based polymers, called “glycopolymers”, in the lab both to better understand biological processes and also to develop potential therapeutics. However, most methods to prepare these molecules are costly and time consuming. Working with PnuVax, we aim to develop a new simple, and efficient method to attach sugars to existing polymers. The method should be applicable to multiple different sugars and polymers, thereby providing a new technology for biological studies and potential therapies.

Intern: 
Jaehak Yu
Faculty Supervisor: 
Elizabeth R. Gillies
Province: 
Ontario
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